Antibiotic DPI: particles, powders, devices and in vitro /in vivo respirability
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چکیده
منابع مشابه
Respirable amikacin dry powders for inhalation by a Quality by Design procedure
Background: Amikacin as a liposomal solution for nebulization is an antibiotic under study for the treatment of Pseudomonas aeruginosa infections in cystic fibrosis patients. In a previous study, the respirability of amikacin dry powders obtained by spray drying was maximized using a Design of Experiment (DoE) approach. This study intended to explore the most influential process and formulation...
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The aim of this study was to prepare dry powder inhalers (DPIs) containing amphotericin B-loaded solid lipid nanoparticles (AMB-SLNs) as an alternative approach for prevention of pulmonary aspergillosis. For solubilizing AMB in small amounts of organic solvents ion paired complexes were firstly formed by establishing electrostatic interaction between AMB and distearoyl phosphatidylglycerol (DSP...
متن کاملPreparation, Statistical Optimization and In-vitro Characterization of a Dry Powder Inhaler (DPI) Containing Solid Lipid Nanoparticles Encapsulating Amphotericin B: Ion Paired Complexes with Distearoyl Phosphatidylglycerol
The aim of this study was to prepare dry powder inhalers (DPIs) containing amphotericin B-loaded solid lipid nanoparticles (AMB-SLNs) as an alternative approach for prevention of pulmonary aspergillosis. For solubilizing AMB in small amounts of organic solvents ion paired complexes were firstly formed by establishing electrostatic interaction between AMB and distearoyl phosphatidylglycerol (DSP...
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Dry powder inhaler (DPI) is a dosage form for delivering fi ne drug powders to the respiratory tract. Particle size and size distribution, proportion of fi nes, particle shape, particle surface roughness, fl ow rate and adhesion force have been reported to affect the aerosolization process. Several mechanisms for particle dispersion in DPI have been considered; a proposed mechanism to explain t...
متن کاملIn-vitro – In-vivo Characterization of Glimepiride Lipid Nanoparticulates Prepared by Combined Approach of Precipitation and Complexation
Novel lipid nanoparticulates (NCs) were developed by a combined approach of precipitation and complexation with an aim to improve the solubility, stability and targeting efficiency of glimepiride (GLP). GLP NCs were prepared by precipitation process using PEG 20000 and further complexed with phospholipon90G (P90G). The NCs were evaluated for physicochemical characterization, such as drug lo...
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